Product Type: Inhibitor
CAS No.: 153436-53-4
MolecularFormula: C16H14ClN3O2
Molecular Weight: 315,8
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO (10 mg/ml)
Appearance: White to light yellow solid
PubChem CID: 2051
Scientific Background: AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.
References: 1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053.2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.