Product Type: Inhibitor
CAS No.: 133550-35-3
MolecularFormula: C16H12N2O3
Molecular Weight: 280,3
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Appearance: Yellow solid
PubChem CID: 5328771
Scientific Background: AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.
References: 1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457.2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.