Product Type: Inhibitor
CAS No.: 133550-30-8
MolecularFormula: C17H14N2O3
Molecular Weight: 294,3
Source: Synthetic
Purity: ≥98% (TLC)
Solubility: Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
Appearance: Tan solid
PubChem CID: 5328779
Scientific Background: AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
References: 1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828.3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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