AGN 196996, CAS 958295-17-5

Product Description: AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).IC50 value: 2 nM(Ki)Target: RARα antagonistAGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Applications: Neuroscience-Neuromodulation

Formula: C24H20BrNO5

References: [1]Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62./[2]Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8.

CAS Number: 958295-17-5

Molecular Weight: 482.32

Compound Purity: 99.76

Research Area: Cancer

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Autophagy;RAR/RXR

• SKU: MEXHY-16682-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-16682-10
• Package Unit: 10 mg
• Quantity Unit: STK