Target: AHA1
Conjugate: ATTO 594
Product Type: Monoclonal
Clone Number: 25F2.D9
Immunogen: Recombinant Full Length Mouse Aha1 Protein
Swiss-Prot: Q8BK64
Purification: Protein G Purified
Storage Buffer: 0.02M potassium phosphate, 0.15M sodium chloride, pH7.2 *Storage buffer may change when conjugated
Concentration: 1.2 mg/ml
Specificity: Detects ~38kDa. Can run up to 45kDa on SDS Page.
Cellular Localization: Cytoplasm,Endoplasmic Reticulum
Scientific Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
References: 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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