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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications
Background: ALK1, also known as activin receptor-like kinase 1 (ACVRL1) is a type I receptor from the TGF-β family of transmembrane serine/threonine kinases. Mutation of ALK1 is seen to play a role in pulmonary arterial hypertension (PAH), Osler-Weber-Rendu syndrome, and vascular smooth muscle cell development.
Description: The ALK1 Kinase Assay Kit is designed to measure ALK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Storage Stability: Up to 6 months when stored as recommended
Supplied As: The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Cunha, Sara I., and Kristian Pietras. ALK1 as an Emerging Target for Antiangiogenic Therapy of Cancer. Blood 117(26): 6999-7006 (2011).
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