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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: ALK2, also known as activin receptor-like kinase 2 (ACVRLK2) is a receptor from the TGF-β family of transmembrane serine/threonine kinases that plays an important role in the bone morphogenic protein (BMP) pathway. Mutation of ALK2 is seen to play a role in cancer and fibrodysplasia ossificans progressiva (FOP).
Description: The ALK2 Kinase Assay Kit is designed to measure ALK2 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed/ Kit components require different storage conditions.Be sure to store each component at the proper temperature upon arrival.
Supplied As: The ALK2 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK2 enzyme, ALK2 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Cunha, Sara I., and Kristian Pietras. "ALK2 as an Emerging Target for Antiangiogenic Therapy of Cancer." Blood 117(26): 6999-7006 (2011).2. Minsung Kim, et al. Identification of novel ALK2 inhibitors and their effect on cancer cells, Biochemical and Biophysical Research Communications, 492(1):121-127 (2017).
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