Product Type: Inhibitor
CAS No.: 237430-03-4
MolecularFormula: C16H11N3O3
Molecular Weight: 293,3
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO; insoluble in water or 100% ethanol
Appearance: Yellow to brown powder
PubChem CID: 5005498
Scientific Background: Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.
References: 1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569.2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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