Product Description: Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs[1].
Applications: Cancer-programmed cell death
Formula: C69H102N11O16P
References: [1]Nareshkumar Jain, et al. Current ADC Linker Chemistry. Pharm Res. 2015 Nov;32(11):3526-40.