Amiodarone Hydrochloride, CAS 19774-82-4

Autophagy inducer

Product Type: Inducer

CAS No.: 19774-82-4

MolecularFormula: C25H29I2NO3•HCl

Molecular Weight: 681,77

Source: Synthetic

Purity: >99 %

Solubility: Soluble to 50 mM in DMSO

Appearance: White solid

PubChem CID: 441325

Scientific Background: Amiodarone is a non-selective ion channel blocker. It has been found, when used in Saccharomyces cerevisiae, to induce an influx of Ca2+ followed by mitochondrial fragmentation and subsequent cell death. Amiodarone has also been shown to induce autophagy by inhibiting mTORC1. Lastly, Amiodarone has broad-spectrum fungicidal activity.

References: 1. Zhang Y., et al. (2007). J Biol Chem. 282(52): 37844-53.2. Balgi A., et al. (2009). PLoS One. 4(9): e7124.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-393-1G
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-393-1G
• Green Labware: No
• Package Unit: 1 g
• Quantity Unit: STK