Formulation: A solid
Formal Name: methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
Purity: ≥70%
Formula Markup: C48H75NO17
Formula Weight: 938,1
Shelf life (days): 1460
CAS Number: 36148-89-7
Notes: Amphotericin B methyl ester is a polyene antiviral and antifungal agent and a derivative of amphotericin B (Item No. 11636).{47976,47977} It impairs viral particle production, as well as viral entry and infectivity, in HIV-1-infected TZM-bl cells when used at a concentration of 10 µM.{47976} Amphotericin B methyl ester also inhibits replication of HIV-1 clinical isolates from a variety of clades in infected human peripheral blood mononuclear cells (PBMCs; IC50s = 0.5-5.5 µM). It is active against S. cerevisiae (MIC = 0.25 µg/ml) and reduces mortality in a mouse model of C. albicans infection when administered at doses of 1 and 10 mg/kg.{47977}
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