Target: Amyloid.
Conjugate: Unconjugated.
Product Type: Polyclonal.
Immunogen: Synthetic molecular mimic of soluble oligomers.
Swiss-Prot: P05067.
Purification: Protein A Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Specificity: Recognizes all types of amyloid oligomers. Appears to recog a peptide backbone epitope common to amyloid oligomers, but not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Cellular Localization: Membrane.
Scientific Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).
References: 1. Glabe C.G. (2004) Trends Biochem Sci. 29(10): 542-547.2. Kayed R., et al. (2004) J Bio. Chem. 279: 46363-46366.3. Kayed R., et al. (2003) Science. 300(5618): 486-489.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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