Target: Ankyrin B
Conjugate: PerCP
Product Type: Monoclonal
Clone Number: N105/13 (Formerly sold as S105-13)
Immunogen: Synthetic peptide amino acids 203-496 of human Ankyrin-B
Swiss-Prot: Q01484
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~200kDa. No cross reactivity against Ankyrin-G.
Cellular Localization: Cytoplasm,Cytoskeleton,Myofibril,Sarcomere,M line,Apical Cell Membrane,Cell Membrane
Scientific Background: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane.
References: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
