Target: Ankyrin G
Conjugate: ATTO 594
Product Type: Monoclonal
Clone Number: N106/20 (Formerly sold as S106-20)
Immunogen: Fusion protein 1000 C-terminal amino acids of human Ankyrin G (also known as ANK-3 or ankyrin-3) encompassing all of Ankyrin G with the exception of Ankyrin repeats
Swiss-Prot: Q12955
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects >~200kDa.
Cellular Localization: Cytoplasm,Cytoskeleton,Cell Projection,Axon,Cell Membrane,Sarcolemma,Cell Junction,Synapse,Postsynaptic Cell Membrane,Lysosome
Scientific Background: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane.
References: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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