Target: Ankyrin R
Conjugate: PerCP
Product Type: Monoclonal
Clone Number: N388A/10 (Formerly sold as S388A-10)
Immunogen: Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R
Swiss-Prot: P16157
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~200kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.
Cellular Localization: Cytoplasm,Cytoskeleton,Myofibril,Sarcomere,M line
Scientific Background: Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).
References: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.2. Genes and mapped phenotypes. (n.d.). Retrieved April 21, 2015, from http://www.ncbi.nlm.nih.gov/gene/286
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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