Formulation: A solid
Formal Name: 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Purity: ≥98%
Formula Markup: C16H11BrN2O2
Formula Weight: 343,2
Shelf life (days): 1460
CAS Number: 882697-00-9
Notes: Anle138b is an inhibitor of protein aggregation.{57703} It inhibits α-synuclein oligomer formation and PrPSc prion propagation by 77 and 84%, respectively, when used at a concentration of 10 µM. Anle138b (1 mg/animal) inhibits brain accumulation of PrPSc in, and increases survival of, prion-infected mice. It reduces brain tau deposition and rescues glucose metabolic decline in a human tau transgenic mouse model of Alzheimer’s disease.{57704} Dietary administration of anle138b (0.6 and 2 g/kg chow) reduces the formation of α-synuclein oligomers and glial cytoplasmic inclusions, microglial activation, and dopaminergic neuron degradation, as well as preserves motor function, in a mouse model of multiple system atrophy (MSA).{57705}
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