CloneID: 3G11
Antigen Long Description: The original antibody was generated by immunizing Balb/c mice with synthesized GAβ.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody is specific for amyloid beta protein-bound GM1.
Application Notes (Clone): The original antibody was generated and screened in vitro via ELISA and Thioflavin T (ThT) fluorescence measurements for its ability to bind to GAβ and inhibit Aβ polymerization. It was assessed in three polymerization systems: (1) polymerization initiated by adding Aβ fibril fragment, (2) Aβ40 polymerization initiated from GAβ40, and (3) Aβ42 polymerization initiated from GAβ42. It showed stronger inhibitory activity, particularly in Aβ40 and Aβ42 polymerization systems, and was found to influence fibril length by promoting fibril shortening or fragmentation rather than just preventing elongation (US7741448B2).
English
Deutsch
