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Applications: Useful for studying expression of CD20 on the cell surface by flow cytometry.
Background: CD20 (also known as MS4A1) is a glycosylated phosphoprotein expressed on the cell surface of B cells. CD20 is a highly attractive target antigen for immunotherapy because it is highly expressed in more than 90% of patients with B-cell lymphoma, but not in the first stage of B cell development. First approved in 1997, Rituximab (Rituxan) is a chimeric monoclonal antibody targeting CD20 and has been classified by the World Health Organization as an "Essential Medicine". Since then, additional monoclonal antibodies against CD20 have been approved or are being tested in clinical trials for the treatment of multiple sclerosis (MS), chronic lymphocytic leukemia (CLL), follicular lymphoma, rheumatoid arthritis, non-Hodgkin's lymphoma, systemic lupus erythematosus, and other inflammatory diseases and cancer types. Studies of CD20 function and expression patterns will continue to broaden our knowledge and application in cancer therapy.
Cross Reactivity: This antibody recognizes human CD20. It has not been tested on other species.
Description: This anti-CD20 antibody is purified recombinant antibody, which is labeled with fluorescein isothiocyanate (FITC). This antibody has been tested by flow cytometry for specific binding to human CD20 on the surface of CD20 CHO Recombinant Cell Line (BPS Bioscience #79624).
Format: Aqueous buffer solution.
Formulation: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 0.09% Sodium Azide, 0.2% BSA, and up to 20% glycerol. May contain a protein stabilizer.
Host Cell Line: HEK293
Purification: Protein A affinity chromatography from HEK293 supernatant.
Purity: ≥90%
Storage Stability: At least 6 months at 4°C. Protect from prolonged exposure to light. DO NOT FREEZE. The antibody solution should be stored undiluted between 2°C and 8°C.
Uniprot: P11836
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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