CloneID: MB22-11
Antigen Long Description: The original antibody was raised by immunizing a CD22-/- mice with mouse CD22.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P35329
Specificity Statement: This antibody is specific for mouse CD22.
Application Notes (Clone): The ability of the original antibody to deplete B cell in vivo in mice was tested. It showed that is was able to deplete B cells NZB/W F1 and C57BL/6 mice. This antibody was used for an ELISA (Haas et al., 2010; PMID:20368280). The ability of this antibody to block the CD22 ligand was tested. It showed that the antibody inhibited CD22-mediated adhesion. This antibody was used in vivo on mice. Here it showed that the antibody was able to significantly reduce B cell numbers (Haas et al., 2006; PMID:16920943).
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