Anti-Crotoxin (CTX-scFv8)

Anti-Crotoxin [CTX-scFv8], Recombinant, Fab fragment lambda, Human

CloneID: CTX-scFv8

Heavy Chain modification: His-Tagged

Antigen Long Description: scFv 8 was constructed from a phage display library using V-genes from 43 non-immunized donors.

Origin Pub PMID: 10736105

Buffer Composition: PBS only.

Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P24027

Specificity Statement: scFv binds to crotoxin and recognises epitopes overlapping BI-a (an epitopic region at the interface between the CA and CB subunits of the heterodimer) and BIII (an epitopic region on CB involved in the enzymatic activity of CB) - scFv 8 may be able to caused the two subunits to dissociate and suppress the synergistic activity between them. Crotoxin is a phospholipase A2 neurotoxin and is the main toxic component in venome from Crotalus durissus terrificus rattlesnakes, acting by blocking neuromuscular transmission.

Application Notes (Clone): scFv 8 is able to reduce the myotoxicity induced by crotoxin and is able to neutralize the lethality induced by the toxin. This scFv was also used for (competitive ELISAs).

• SKU: ABAAb00760-10.6-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab00760-10.6-BT
• Package Unit: 500 μg
• Quantity Unit: STK
• Reactivity: Various species
• Clonality: Recombinant
• Application: ELISA, Neutralization
• Isotype: Fab fragment lambda
• Host: Human