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Applications: Useful for inhibition of CTLA4:B7 interactions.
Assay Conditions: Antibody was added toCTLA4:B7.1 binding assay at variousconcentrations. Assay was done according toBPS Cat. #72009 protocol.
Description: Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of CTLA4 and blocking binding of CTLA4 to B7.1 and B7.2. This antibody recognizes human CTLA4 but does not bind to murine CTLA4. This antibody has not been tested for cross-reactivity with other species.
Endotoxin Level: <1 EU/µg
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Purification: Protein A affinity chromatographyfrom HEK293 supernatants.
Storage Stability: Stable for at least 12 months at-80°C.
Uniprot: P16410
Warnings: Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.
Biosafety Level: Not applicable (BSL-1)
References: 1. Linsley, P.S., et al., J. Exp. Med. 1991; 174(3): 561-569.
2. Hurwitz, A.A., et al., Canc. Res. 2000; 60: 2444-2448.
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