CloneID: 6E
Heavy Chain modification: ScFv
Antigen Long Description: The original antibody was isolated from a human Tomlinson I and J scFv antibody libraries by panning the library against fibrillar α-synuclein prepared as per the method given in PMID: 16984950.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human scFv antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P37840
Specificity Statement: This antibody recognizes the fibrillar morphological form of human alpha-synuclein. Alpha-synuclein is a small 140 amino acid presynaptic neuronal protein, a major component of Lewy bodies and a member of the synuclein family. Misfolding, abnormal accumulation, and secretion of α-Synuclein (α-Syn) are closely associated with synucleinopathies, including Parkinson’s disease (PD). α-syn is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, α-syn is found mainly at the tips of neurons in the specialized structures known as presynaptic terminals and has been shown to comprise up to ∼1% of total proteins in the neuronal cytosol. Recent evidence suggests that α-synuclein (α-syn) can contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS).
Application Notes (Clone): The binding of this antibody to fibrillar alpha-synuclein was confirmed using ELISA. This antibody is not capable of recognizing monomeric and oligomeric forms of alpha-synuclein (PMID: 16984950).
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