Target: MHC Class I.
Clone: W6/32.
Specificity: Anti-MHC Class I In Vivo Antibody - Low Endotoxin (W6/32) recognizes/reacts with major histocompatibility complex (MHC) class I, HLA-A, B, and C.
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: This HLA-A, B, C antigen is present on most nucleated cells of humans and old world monkeys.
Background: MHC class I antigens associated with β2-microglobulin are expressed by all human nucleated cells. MHC class I molecules are involved in the presentation of antigens to CD8+ T cells and plays a central role in cell-mediated immune responses and tumor surveillance.
Immunogen: Human tonsil cell membrane.
Concentration: 1.0 mg/ml.
Formulation: No carrier proteins or preservatives in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl.
Purity: >95% by SDS-PAGE and HPLC.
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method.
Aggregation: Aggregation level ≤ 5%.
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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