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Encompassing Amino Acids: 25-776
Application: Useful for studying the binding and neutralization of IL-12B (Interleukin-12 subunit beta) interaction with IL12Rβ1 in ELISA and in cellular assays.
Assay Conditions: Assay was done according to IL12B:IL12RB1 [Biotinylated] Inhibitor Screening Chemiluminescence Assay Kit (#82581) with increasing amounts of Anti-IL-12 p40/ IL-12B Antibody.
Background: IL-12B (Interleukin-12 subunit beta) encodes the p40 subunit of the heterodimeric cytokine IL-12, which functions alongside the p35 subunit (encoded by IL-12A). The IL12Rβ1 receptor subunit interacts with IL-12B and plays a crucial role in the IL-12 and IL-23 signaling pathways, promoting Th1 cell differentiation and IFN-γ (Interferon-γ) production. Anti-p40 neutralizing antibodies, which target the p40 subunit common to both IL-12 and IL-23, are primarily used as therapeutic agents for autoimmune and inflammatory diseases. These antibodies, such as Ustekinumab, have demonstrated significant efficacy in conditions such as psoriasis, psoriatic arthritis, and Crohn's disease by reducing inflammatory responses and modulating immune activity. The continued exploration of these antibodies holds promise for expanding their use to other immune-related conditions and improving patient outcomes.
Clone Number: Monoclonal
Description: This anti-IL-12 p40/ IL-12B antibody is a purified, humanized recombinant monoclonal antibody that recognizes human p40 (also known as IL-12B). This antibody has been tested for neutralization of IL-12B (Interleukin-12 subunit beta) interaction with IL12Rβ1 (IL-12 receptor beta 1) in a binding assay. This antibody is similar to Ustekinumab.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Purity: ≥90%
Storage Stability: -80°C
Supplied As: At least 6 months at -80°C.
Tags: CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2, Interleukin-12 Subunit Beta, Ustekinumab
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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