Target: LAG3.
Clone: C9B7W.
Specificity: Anti-LAG-3 In Vivo Antibody - Low Endotoxin (C9B7W) recognizes an epitope on Mouse LAG-3.
Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: T-cells and NK cells.
Background: LAG-3, also known as CD223, is 70 kD type I transmembrane glycoprotein within the Ig superfamily. CD223, like CD4, binds MHC class II molecules, but with higher affinity than CD4. Clone C9B7W antibody has been reported to block the function of murine LAG-3 in vivo and in vitro.
Immunogen: Murine CD223-Ig fusion protein.
Concentration: 1.0 - 5.0 mg/ml.
Formulation: 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Purity: >95% by SDS-PAGE and HPLC.
Endotoxin: ≤ 1.0 EU/mg as determined by the LAL method.
Aggregation: Aggregation level ≤ 5%.
Use: Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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