CloneID: A2C7
Antigen Long Description: This antibody was prepared by intranasally infecting BALB/c mice with an attenuated vaccinia virus (VACV) mutant, followed by a boost with an intravenous injection of UV-inactivated WT VACV.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the VACV antigen A33, a viral glycoprotein associated with the outer membrane of extracellular enveloped viruses. A33 is known to elicit protective antibody responses.
Application Notes (Clone): The specificity of this antibody for VACV has been confirmed by IF assays (Meng, 2011). This antibody exhibited strong complement-mediated neutralization of the extracellular enveloped form of vaccinia virus in the presence of complement, and was able to protect mice against weight loss and death following an in vivo VACV challenge (Matho, 2015).
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