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Applications: This product is for research use only. It is not suitable for human, diagnostic or therapeutic use. The human monoclonal neutralizing IgG can be used for functional assays to block VISTA and VSIG3 binding
Assay Conditions: The functional activity of the antibody was measured using VSIG-3:VISTA [Biotinylated] Inhibitor Screening Assay Kit (BPS Bioscience #79782)
Description: This human monoclonal antibody recognizes human V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA), and neutralizes its interaction with VSIG3 (also called IGSF11). VISTA is also known as B7-H5 or VSIR (GenBank Accession No. NM_022153). VSIG3 is a ligand involved in cell adhesion as a VISTA binding partner. This neutralizing antibody has been functionally tested using the VSIG-3:VISTA [Biotinylated] Inhibitor Screening Assay Kit (BPS Bioscience #79782).
Format: Aqueous buffer solution
Formulation: 8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, 20% glycerol
Storage Stability: Store in aliquots at -80°C. Stable for at least 12 months from date of receipt.
Uniprot: Q9H7M9
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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