Product Description: Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257)[1].
Applications: Cancer-programmed cell death
Formula: C10H15Cl4N5O2
References: [1] Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.
CAS Number: 1683535-53-6
Molecular Weight: 379.07
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: APC;Ligands for Target Protein for PROTAC