APE1 blocking peptide

Species: Human

Specificity/Sensitivity: The peptide was used in the production of GTX89912.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservative.

Concentration:

Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Region Sequence: PKRGKKGAVAEDGD-C

Full Name: APEX nuclease (multifunctional DNA repair enzyme) 1

• SKU: GTX89912-PEP-100
• Manufacturer: GeneTex
• Manufacturer SKU: GTX89912-PEP-100
• Green Labware: No
• Package Unit: 100 μg
• Quantity Unit: STK
• Reactivity: Human
• Application: ELISA, Blocking, Affinity Purification
• Human Gene ID: 328