Product Description: Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1].
Applications: COVID-19-immunoregulation
Formula: C19H27N3OS
References: [1]Xu D, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587(7832):133-138.
CAS Number: 2559703-06-7
Molecular Weight: 345.50
Compound Purity: 99.84
Research Area: Inflammation/Immunology
Solubility: DMSO : 83.33 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 80°C)
Target: Apoptosis;Autophagy;Beclin1;Necroptosis;RIP kinase
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