Target: Aquaporin 3.
Conjugate: Biotin.
Product Type: Polyclonal.
Immunogen: Produced against the C-terminal peptide (Sequence N-CHLEQPPPSTEAENVKLAHMKHKEQI) of rat aquaporin 3.
Swiss-Prot: P47862.
Purification: Protein A Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~31.5kDa. May detect larger glycosylated bands ~35-50kDa.
Cellular Localization: Membrane.
Scientific Background: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 3 is found in the basolateral cell membrane of principal collecting duct cells and provide a pathway for water to exit these cells (3). AQP3 gene expression is not regulated by vasopressin (4).
References: 1. Gonen T., Walz T. (2006) Q. Rev. Biophys. 39(4): 361-396.2. Knepper M.A. (1994) Proc Natl. Acad Sci. USA. 91(14): 6255-6258.3. Sasaki S., Ishibashi K., and Marumo F. (1998) Annu Rev Physiol. 60: 199-220.4. Dibas A.I., Mia A.J., Yorio T. (1998) Proc Soc Exp Med. 219(3): 183-199.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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