Conjugation: FITC: Fluorescein Isothiocyanate
Description of Target: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. ARG2 (type II isoform) is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism.Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human ARG2
Key Reference: Mumenthaler,S.M., (2008) Int. J. Oncol. 32 (2), 357-365
Molecular Weight: 39kDa
Peptide Sequence: Synthetic peptide located within the following region:
SALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTProduct Format: Liquid. Purified antibody supplied in 1x PBS buffer.
Protein Name: Arginase-2, mitochondrial
Protein Size: 354
Purification: Affinity Purified
English
Deutsch
