Formulation: A solid
Formal Name: 2-methyl-2-propenoic acid, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester
Purity: ≥98%
Formula Markup: C19H24O5
Formula Weight: 332,4
Shelf life (days): 1460
CAS Number: 34532-68-8
Notes: Arnicolide D is a sesquiterpene lactone that has been found in Centipeda minima and has anticancer activity.{68185} It inhibits the proliferation of MDA-MB-231, MDA-MB-468, and MCF-7 human breast cancer cells (IC50s = 5.211, 3.405, and 9.083 µM, respectively, after 48 hours). It induces apoptosis and cell cycle arrest at the G2/M phase in MDA-MB-468 and MDA-MB-231 cells. Arnicolide D (2.5, 5, and 10 µM) inhibits migration of MDA-MB-231 cells. It also reduces protein levels of Akt, phosphorylated Akt, mammalian target of rapamycin (mTOR), phosphorylated mTOR, and STAT3 in MDA-MB-231 cells in a concentration-dependent manner. Arnicolide D (25 or 50 mg/kg) reduces tumor volume in an MDA-MB-231 orthotopic mouse xenograft model.
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