Conjugation: HRP: Horseradish Peroxidase
Description of Target: ARSA hydrolyzes cerebroside sulfate. Defects in ARSA are a cause of leukodystrophy metachromatic (MLD).The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Multiple alternatively spliced transcript variants, one of which encodes a distinct protein, have been described for this gene.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ARSA
Key Reference: Saito,S., (2008) Mol. Genet. Metab. 93 (4), 419-425
Molecular Weight: 52kDa
Peptide Sequence: Synthetic peptide located within the following region:
KQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPDPHProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Arylsulfatase A
Protein Size: 507
Purification: Affinity Purified
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