(Asp371)-Tyrosinase (369-377) (human) (trifluoroacetate salt)

Formulation: A solid

Formal Name: (2S,5S,8S,11S,14S,20S)-20-((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-4-(methylthio)butanamido)-5-(3-amino-3-oxopropyl)-14-((R)-1-hydroxyethyl)-8-(hydroxymethyl)-2-isopropyl-11-(2-(methylthio)ethyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid, trifluoroacetate salt

Purity: ≥98% (mixture of isomers)

Formula Markup: C42H66N10O16S2 • XCF3COOH

Formula Weight: 1031,2

Shelf life (days): 1460

Notes: [Asp371]-Tyrosinase (369-377) is a naturally occurring tyrosinase antigen peptide.{69703} It is formed via post-translational modification of Asn371.{69704} [Asp371]-Tyrosinase (369-377) binds to MHC class I subtype HLA-A*0201-positive T2 cells (IC50 = 1.2 µg/ml) and induces lysis of HLA-A2.1-positive T2 cells incubated with cytotoxic T lymphocytes in a concentration-dependent manner.{69705,69703} Immunization with [Asp371]-tyrosinase (369-377)-pulsed, CD40L-activated autologous dendritic cells delays tumor growth in an AAD-expressing B16-F1 melanoma model using transgenic mice expressing HLA-A*0201 linked to the CD8-binding domain of H-2Dd (AAD).{69706}

• SKU: CAY40152-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40152-5
• Package Unit: 5 mg
• Quantity Unit: STK