Product Type: Inhibitor
CAS No.: 68844-77-9
MolecularFormula: C28H31FN4O
Molecular Weight: 458,57
Source: Synthetic
Purity: >98%
Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
Appearance: White solid
PubChem CID: 2247
Scientific Background: Astemizole is a second generation antihistamine drug which has a long duration of action. It binds to histamine H1-receptor sites in the gastrointestinal tract, uterus, blood vessels and bronchial muscle. It does not cross the blood-brain barrier, and the binding is primarily in the peripheral nervous system (1). It is metabolized by CYP3A4 (2).
References: 1. Laduron P.M., Janssen P.F., Commeren W. and Leysen J.E. (1982) Mol Pharmacol. 21(2): 294-300.2. Maysumoto S., Yamazoe Y. (2001) Br. J Clin Pharamcol. 51(2): 133-142.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
English
Deutsch
