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Applications: Great for studying enzyme kinetics and HTS applications.
Background: Human Ataxin-3 (ATX3 or ATXN3), also known as Josephin (JOS) or Machado-Joseph disease protein 1 (MJD1), is implicated in Machado-Joseph disease, a neurological disease that progresses cerebellar ataxia. It is also clinically relevant in gastric, lung, and testicular cancers.
Description: The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps.
Storage Stability: At least one year from date of receipt when stored as directed.
Supplied As: The kit comes in a convenient 96-well format, with purified Ataxin-3 protein, Ubiquitin-AMC, and Ataxin-3 assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Shi, Z., et al. 2018. Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN. Biochem Biophys Res Commun. 503(1):391-396. doi:10.1016/j.bbrc.2018.06.047
2. Koch, P., et al. 2011. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480(7378): 543-546.
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