Product Type: Inhibitor
CAS No.: 34031-32-8
MolecularFormula: C20H34AuO9PS
Molecular Weight: 678,5
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO (5 mg/ml) or 100% ethanol (4 mg/ml)
Appearance: White solid
PubChem CID: 24199313
Scientific Background: Auranofin is derivative of gold and has been widely used as an anti-arthritic drug. It inhibits both leukocyte activation pathways at multiple sites and the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin has been shown to inhibit human neutrophil 5-lipoxygenase, thioredoxin reductase (TrxR), IκB kinase (IKK).
References: 1. Betts W.H., Hurst N.P., Murphy G.A., & Cleland L.G. (1990) Biochem. Pharm. 39(7). 1233–1237.2. Rudkowski R., Ziegler J.B., Graham G.G., & Champion G.D. (1991) Biochem. Pharm. 41(12): 1921–1929.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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