Abbreviation: AXIN2
Target Synonym: AXIN2;AXIL;ODCRCS;axin-2
Conjugation: Unconjugated
UNIProt ID: Q9Y2T1
Background: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human AXIN2
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200
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