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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: AXL (TYRO7) is a receptor tyrosine kinase that is overexpressed in various forms of cancer, including breast, prostate, colorectal, and non-small cell cancers. AXL overexpression has been shown to encourage tumor progression and metastasis and to decrease the anti-tumor immune response, making AXL an attractive candidate for anticancer therapies.
Description: The AXL Kinase Assay Kit is designed to measure AXL kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The AXL Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant AXL enzyme, AXL substrate, ATP and kinase assay buffer for 100 enzyme reactions
Storage Stability: Up to 6 months when stored as recommended.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Wu, X., Liu, X., Koul, S., Lee, C.Y., Zhang, Z., Halmos, B. AXL kinase as a novel target for cancer therapy. Oncotarget. 2014; 5(20):9546-63.2. Rankin, E.B., Giaccia, A.J. The Receptor Tyrosine Kinase AXL in Cancer Progression. Cancers (Basel). 2016; 8(11):103.
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