AZ 7550 (hydrochloride)

Formulation: A solid

Formal Name: N-[4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[methyl[2-(methylamino)ethyl]amino]phenyl]-2-propenamide, hydrochloride

Purity: ≥98%

Formula Markup: C27H31N7O2 • XHCl

Formula Weight: 485,6

Shelf life (days): 1460

Notes: AZ 7550 is an active metabolite of AZ 9291 (Item No. 16237).{27820} It inhibits the insulin-like growth factor 1 receptor (IGF-1R) in a cell-free assay (IC50 = 1.6 µM). It inhibits EGFR autophosphorylation in H1975 and PC-9 cells expressing the respective constitutively active mutants EGFRT790M/L858R and EGFRExon19del (IC50s = 0.045 and 0.026 µM, respectively), as well as in LoVo cells expressing wild-type EGFR (IC50 = 0.786 µM).

• SKU: CAY40753-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40753-1
• Package Unit: 1 mg
• Quantity Unit: STK