AZ12601011, CAS 2748337-86-0

Description: AZ12601011 is an orally active, selective and potent TGFBR1 kinase inhibitor.AZ12601011 inhibits the release of inflammatory factors, interleukin (IL)-1β, IL-6 and tumor necrosis factor-α, and inhibits the growth of breast tumors.AZ12601011 directly binds to TGF-βR1 and blocks downstream Smad3 activation, which can be used to prevent renal fibrosis.

CAS Number: 2748337-86-0

Formula: C19H15N5

Molecular Weight: 313,36

References: Spender LC, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor βSuperfamily Type 1 Receptors. Mol Pharmacol. 2019 Feb;95(2):222-234.

• SKU: TGMT10426-1mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T10426-1mg
• Package Unit: 1 mg
• Quantity Unit: STK