AZD1283, CAS 919351-41-0

Product Description: AZD1283 is a potent P2Y12 receptor antagonist with a binding IC50 of 11 nM and a GTPγS IC50 of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders[1][2].

Applications: COVID-19-immunoregulation

Formula: C23H26N4O5S

References: [1]Bach P, et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56(17):7015-24./[2]Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62(6):3088-3106.

CAS Number: 919351-41-0

Molecular Weight: 470.54

Compound Purity: 99.33

Research Area: Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: P2Y Receptor

• SKU: MEXHY-15799-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15799-10.1
• Package Unit: 10mM/1mL
• Quantity Unit: STK