b-AP15 (NSC-687852) , CAS 1009817-63-3

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Applications: Suitable for validation studies of the deubiquitinating activities of the 19S regulatory particle as a drug target, as well as cell-based and in vitro characterization UCH-L5 or USP14 activity.

CAS Number: 1009817-63-3

Description: Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.

Format: Pale yellow powder

Purity: ≥98% by HPLC.

Solubility: Soluble in DMSO (35 mg/ml)

Warnings: Protect from moisture.

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS27701-1
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27701-1
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK