Product Type: Inhibitor
CAS No.: 88899-55-2
MolecularFormula: C35H58O9
Molecular Weight: 622,84
Source: Synthetic
Purity: >98% HPLC; NMR (Conforms)
Solubility: May be dissolved in DMSO (50mg/mL)
Appearance: White powder to colorless film.
PubChem CID: 6436223
Scientific Background: Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.
References: 1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212.2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16.3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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