Target Synonym: BAG family molecular chaperone regulator 3 ;BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; BIS
Conjugation: Unconjugated
UNIProt ID: O95817
Background: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70.
Concentration: 0.4mg/mL
Immunogen: Recombinant Human BAG3 protein expressed by E.coli