Target: Bassoon.
Conjugate: ATTO 594.
Product Type: Polyclonal.
Immunogen: NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein.
Swiss-Prot: Q9UPA5.
Purification: Protein A Purified.
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Detects ~420kDa. Multiple isoforms can be detected.
Cellular Localization: Cytoplasm, Cell Junction, Synapse.
Scientific Background: Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
References: 1. Anna Dondzillo et al., (2010) J. Comp Neur, 518(7): 1008–1029.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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