Solubility: Soluble to 25 mM in ethanol and to 100 mM in DMSO
Appearance: White solid
PubChem CID: 5353431
Scientific Background: BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
References: 1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.