BAY-1161909, CAS 1443763-60-7

Formulation: A solid

Formal Name: (αR)-4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]-α-methyl-benzeneacetamide

Purity: ≥98%

Formula Markup: C29H26FN5O4S

Formula Weight: 559,6

Shelf life (days): 1460

CAS Number: 1443763-60-7

Notes: BAY-1161909 is an inhibitor of monopolar spindle 1 (Mps1; IC50 = 0.34 nM).{34467} It inhibits metaphase arrest induced by the antimitotic agent nocodazole (Item No. 13857) in HeLa cells (IC50 = 56 nM). BAY-1161909 inhibits proliferation in a panel of 86 cancer cell lines (median IC50 = 6.7 nM). In vivo, BAY-1161909 (2.5 mg/kg) reduces tumor area in a cisplatin-resistant A2780/CP70 ovarian cancer mouse xenograft model.

• SKU: CAY41108-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41108-1
• Package Unit: 1 mg
• Quantity Unit: STK