Target: Beclin 1.
Conjugate: Unconjugated.
Product Type: Polyclonal.
Immunogen: Synthetic peptide from the mid-protein of human Beclin 1.
Swiss-Prot: Q14457.
Purification: Peptide Affinity Purified.
Storage Buffer: PBS, 50% glycerol, 0.09% sodium azide.
Concentration: 1 mg/ml.
Specificity: Predicted molecular weight at ~51kDa. Observed a secondary band on some lysates at ~30kDa.
Cellular Localization: Cytoplasm, Golgi apparatus, Trans-Golgi network membrane, Endosome, Endoplasmic reticulum membrane, Mitochondrion, Mitochondrion membrane, Cytoplasmic vesicle, Autophagosome.
Scientific Background: Beclin 1 is the mammalian ortholog of the yeast autophagy -related gene Atg6. It regulates autophagy and has an important role in development, tumorigenesis and neurodegeneration (1). Beclin 1 is localized within cytoplasmic structures including the mitochondria, yet overexpression reveals some nuclear staining (2). Researchers have found that schizonphrenia is associated with low levels of Beclin-1 in the hippocampus (3). It may also protect against infection by a neuorvirulent strain of Sindbis virus (4).
References: 1. Zhong Y., et al. (2009) Nat Cell Biol. 11(4): 468-476.2. Liang X.H., et al. (2001) Cancer Res. 61: 3443-3449.3. Merenlender-Wagner A., et al. (2013) Mol. Psychiatry 20:126-132.4. Liang X.H., et al. (1998) J Virol. 72: 8586-8596.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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